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Cerebellar Atrophy Following Acute Intoxication with Phenytoin Neurol 39:432-433, Masur,H.,et al, 1989 See this aricle in Pubmed Article Abstract A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin.The clinical signs of cerebellar dysfunction subsided very slowly and incompletely within 18 months.We documented the cerebellar atrophy by CTs 4 weeks and 1 year after the intoxication,and we suggest that a single severe acute intoxication with phenytoin may directly cause cerebellar degeneration.

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